Two Kinds of How Are You?

Some people ask how are you and could care less what your answer is. Even people who have known you for years. I am sure I was guilty at times. 

1) I honestly care about your condition in this world . You are  saying please let me know what is going on in your life. 

2) I really do not care how are you. Just say something that I won't care about the answer so I can tell you what I want from you.